Elphaba (Cynthia Erivo), now demonized as The Wicked Witch of the West, lives in exile, hidden within the Ozian forest while continuing her fight for the freedom of Oz's silenced Animals and desperately trying to expose the truth she knows about The Wizard (Jeff Goldblum). Glinda, meanwhile, has become the glamorous symbol of Goodness for all of Oz, living at the palace in Emerald City and reveling in the perks of fame and popularity. Under the instruction of Madame Morrible (Oscar® winner Michelle Yeoh), Glinda is deployed to serve as an effervescent comfort to Oz, reassuring the masses that all is well under the rule of The Wizard. As Glinda's stardom expands and she prepares to marry Prince Fiyero (Olivier award winner and Emmy and SAG nominee Jonathan Bailey) in a spectacular Ozian wedding, she is haunted by her separation from Elphaba. She attempts to broker a conciliation between Elphaba and The Wizard, but those efforts will fail, driving Elphaba and Glinda only further apart.

The Four Horsemen return along with a new generation of illusionists performing mind-melding twists, turns, surprises, and magic unlike anything ever captured on film.